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在营养不良病人中,许多药物的药代动力学会改变。例如氨基糖苷类的分布容积(Vd)在标准体重以下时近0.35L/kg,庆大霉素约在0.44L/kg,均大于已公布的正常Vd(近0.25L/kg),在特殊情况下的病人,庆大霉素剂量要根据Vd或其他参数调整。药代动力学评价曾用过NPD、二步法(STS)和NONMEM程序算法。NPEM(Nonparame-tric Expectation Maximisation)算法是新介绍的药代动力学PC微机程序评价法,可用少量测定值获得药代动力参数进行给药方案的设计。
In malnourished patients, the pharmacokinetics of many drugs can change. For example, the distribution volume (Vd) of aminoglycosides is approximately 0.35 L / kg below the standard body weight and about 0.44 L / kg of gentamycin is greater than the published normal Vd (approximately 0.25 L / kg) Under the patient, gentamicin dose to be adjusted according to Vd or other parameters. Pharmacokinetic evaluation has used NPD, two-step method (STS) and NONMEM algorithm. NPEM (Nonparametric-tric Expectation Maximization) algorithm is a newly introduced pharmacokinetic PC computer program evaluation method, which can be used to obtain pharmacokinetic parameters with a small amount of measured values for the design of drug delivery scheme.