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本文报道按随机抽样对27例早期钩体病患者应用首剂青霉素5万单位和40万单位肌注治疗,赫氏反应发生率无显著差异。认为首剂青霉素以中等剂量为宜,即首剂40万单位肌注,4小时后,继以40万单位肌注Q8h,疗程5～7天.病程长、病情危重者,可适当加大剂量和延长疗程.若毒血症状重,病程又值肺弥漫性出血的好发期,可在首剂青霉素的同时给氢化考的松500mg.4小时内静脉滴入,以预防赫氏反应,减少肺弥漫性出血的发生。
This article reports a random sample of 27 cases of early leptospirosis patients with the first dose of penicillin 50,000 units and 400,000 units of intramuscular injection treatment, the incidence of Herz ’s reaction was no significant difference. That the first dose of penicillin moderate dose is appropriate, the first dose of 400,000 units intramuscular injection, 4 hours later, followed by 400,000 units intramuscular injection Q8h, treatment of 5 to 7 days long duration, critically ill, may be appropriate to increase the dose And prolong the course of treatment.If the severe symptoms of sepsis, duration of pulmonary diffuse bleeding episodes, the first dose of penicillin can give hydrocortisone 500mg.4 hours intravenous infusion to prevent Heath reaction, reduce Pulmonary diffuse hemorrhage occurred.