谷氨酸是哺乳动物中枢神经系统中重要的兴奋性神经递质,然而对其转运蛋白的研究至今还不十分清楚。ＲｅｉｎｈａｒｄＪａｈｎ等在纯化谷氨酸转运蛋白ＢＮＰＩ(依赖Ｎａ+的磷酸转运囊泡结合蛋白)后,发现它的底物选择性和能量依赖性与突触囊泡对谷氨酸的摄取非常相似。他们首先确 Glutamic acid is an important excitatory neurotransmitter in mammalian central nervous system. However, the study on its transporter is still not clear yet. Reinhard Jahn et al. Found that substrate selectivity and energy dependence of the purified glutamate transporter BNPI, a Na + -based phosphate transport vesicle binding protein, were found to be very similar to the uptake of glutamate by synaptic vesicles. They first confirm