目的探讨乳腺原发性恶性淋巴瘤组织学类型、临床病理特点及鉴别诊断。方法收集3例乳腺原发性恶性淋巴瘤临床病理资料,对其进行HE染色和免疫组化标记。结果3例乳腺原发性恶性淋巴瘤,2例为弥漫性大B细胞淋巴瘤,1例为粘膜相关淋巴组织淋巴瘤;LCA、CD20和bc l-2染色均为阳性,AE1/AE3、CD45RO、CD10和bc l-6阴性。结论乳腺原发性恶性淋巴瘤罕见,诊断主要依靠病理组织形态学和免疫组织化学标记。 Objective To investigate the histological types, clinical pathological features and differential diagnosis of primary malignant lymphoma in breast. Methods The clinical data of 3 cases of primary malignant lymphoma of breast were collected and stained with HE and labeled with immunohistochemistry. Results Three cases of primary malignant lymphoma of the breast, two cases of diffuse large B-cell lymphoma and one case of mucosa-associated lymphoid tissue lymphoma were positive for LCA, CD20 and bc l-2 staining, AE1 / AE3 and CD45RO , CD10 and bc l-6 negative. Conclusions Breast primary malignant lymphoma is rare and the diagnosis mainly depends on histopathology and immunohistochemistry.