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目的:探讨盐酸曲马多联合复方苦参注射液的三阶梯疗法治疗癌性疼痛(癌痛)的临床疗效与不良反应。方法:将80例癌痛患者随机分为两组各40例,对照组予WHO三阶梯法治疗,治疗组予盐酸曲马多联合复方苦参注射液的三阶梯法治疗,均连续用药并观察2 d,观察两组治疗前、治疗后1h、3h、6h、12h(T0-T12)的疼痛强度(PI)、镇痛分(ANS)、疼痛强度差(PID)、疼痛缓解度(PR)、疼痛缓解率(PRR)、总疼痛缓解度(TPR)、总疼痛强度差(SPID)、总镇痛分(TANS)等指标。结果:治疗组起效时间与对照组相似,但起效后治疗组镇痛作用优于对照组,且有效止痛时间较长(P<0.05或P<0.01)。治疗组疼痛缓解度及疼痛缓解率均优于对照组(P<0.05)。治疗组TPR、SPID、TANS均优于对照组(P<0.05或P<0.01)。治疗组的不良反应较对照组少且轻微。结论:盐酸曲马多联合复方苦参注射液的中西医结合三阶梯法治疗癌痛疗效肯定,不良反应少。
Objective: To investigate the clinical efficacy and adverse reactions of tramadol combined with compound Kushen injection in the treatment of cancer pain (cancer pain). Methods: Eighty patients with cancer pain were randomly divided into two groups of 40 cases. The control group was treated by the WHO three-step method. The treatment group was given triple trapezoidal treatment with tramadol hydrochloride combined with Compound Kushen Injection. All patients were continuously treated and observed The pain intensity (PI), analgesia score (ANS), pain intensity difference (PID), pain relief degree (PR) and the degree of pain relief were observed before and 2, , Pain relief rate (PRR), total pain relief (TPR), total pain intensity (SPID), total analgesia score (TANS) and other indicators. Results: The onset time of the treatment group was similar to that of the control group, but after the onset of treatment, the analgesic effect of the treatment group was better than that of the control group, and the effective analgesic time was longer (P <0.05 or P <0.01). The treatment group pain relief and pain relief rate were better than the control group (P <0.05). TPR, SPID and TANS in the treatment group were better than those in the control group (P <0.05 or P <0.01). Adverse reactions in the treatment group were less and less than those in the control group. Conclusion: Tramadol hydrochloride combined with compound matrine injection of traditional Chinese and western medicine combined with three-step method for the treatment of cancer pain, positive effects, fewer adverse reactions.