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目的:研究辛伐他汀抗心肌肥厚作用,方法:部分狭窄腹主动脉,大鼠ig辛伐他汀8周后进行各项指标测定,结果:8周后,左心室肥大(LVH)大鼠左心室重量(LVW),左心室重量/体重(LVW/BW),左右心室重量比(LVW/RVW),左心室舒张末期压力(LVEDP)和羟脯氨酸的含量分别比假手术组大鼠增加36％,51％,28％,92％和23％(P<0.01),LV+dp/dt_(max)和-dp/dtr_(max)分别减少39.2％和39.4％(P<0.01),辛伐他汀ig 8周(3.6mg·kg~(-1)·d~(-1)使LVW,LVW/BW,LVW/RVW,LVEDP和羟脯氨酸的含量分别比LVH大鼠减少22％,21％,23％,24％,和11％(P<0.01),结论:辛伐他汀抑制大鼠左心室肥大的形成,改善左心室功能。
Objective: To study the anti-hypertrophy effect of simvastatin. Methods: After some weeks, some indicators of narrow aorta and ig simvastatin were measured. After 8 weeks, the left ventricular The levels of LVW, LVW / BW, LVW / RVW, LVEDP and hydroxyproline were increased by 36 LV + dp / dt max and -dp / dtr max decreased by 39.2% and 39.4% (P <0.01), respectively The levels of LVW, LVW / BW, LVW / RVW, LVEDP and hydroxyproline decreased by 22% in statin group compared with those in LVH group after 8 weeks (3.6 mg · kg -1 · d -1), respectively %, 23%, 24%, and 11%, respectively (P <0.01). Conclusion: Simvastatin can inhibit left ventricular hypertrophy and improve left ventricular function in rats.