目的:比较艾普拉唑与埃索美拉唑三联疗法治疗幽门螺杆菌(Hp)阳性十二指肠溃疡(DU)的近期疗效。方法:120例Hp阳性的DU患者随机分为3组,分别给予艾普拉唑15 mg、20 mg、埃索美拉唑20mg,同时给予克拉霉素0.5g、阿莫西林1.0g,bid,共10d。根除Hp结束后3组患者分别继续给予相应剂量质子泵抑制药治疗4周,于2周末和4周末复查胃镜并检测Hp,观察患者溃疡愈合率、Hp根除率及药品不良反应。结果:2周末3组溃疡愈合率分别为82.5%、75%、77.5%(P>0.05);4周末溃疡愈合率分别为90%、87.5%、87.5%(P>0.05)。3组Hp根除率分别为85%、82.5%、90%(P>0.05)。3组均未见严重不良反应。结论:艾普拉唑三联疗法治疗Hp阳性DU能有效缓解症状,促进溃疡愈合,安全有效,疗效与剂量无明显线性关系,与埃索美拉唑临床疗效差异不明显。 Objective: To compare the short-term efficacy of Iprazolam and esomeprazole triple therapy in the treatment of Helicobacter pylori (Hp) -positive duodenal ulcer (DU). Methods: One hundred and twenty Hp positive DU patients were randomly divided into three groups: 15 mg of Ilaprazole, 20 mg of esomeprazole and 20 mg of esomeprazole respectively. Meanwhile, 0.5 g of clarithromycin, 1.0 g of amoxicillin, A total of 10d. After the eradication of Hp, the three groups were given the corresponding dose of proton pump inhibitor for 4 weeks respectively. Gastroscopy was performed at the end of 2 and 4 weeks to detect Hp. The ulcer healing rate, Hp eradication rate and adverse drug reactions were observed. Results: The healing rates of three groups were 82.5%, 75% and 77.5% respectively at 2weeks (P> 0.05). The ulcer healing rates at 4weeks were 90%, 87.5% and 87.5%, respectively. The three groups of Hp eradication rates were 85%, 82.5%, 90% (P> 0.05). No serious adverse reactions were observed in all three groups. Conclusion: Iprazole triple therapy for Hp positive DU can effectively relieve the symptoms and promote the healing of ulcer, which is safe and effective. There is no significant linear relationship between the efficacy and dosage, and there is no significant difference between the two groups.