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目的研究紫杉醇联合阿霉素治疗局部晚期乳腺癌的临床效果。方法选取广西梧州市工人医院2008—2015年收治的局部晚期乳腺癌患者110例,按照随机数字表法分为A组和B组,每组55例。A组患者给予紫杉醇联合阿霉素治疗,B组患者给予卡培他滨联合阿霉素治疗。比较两组患者的临床效果及毒副作用发生情况。结果A组患者治疗总有效率高于B组,差异有统计学意义(P<0.05)。两组患者治疗后毒副作用发生率比较,差异无统计学意义(P>0.05)。结论紫杉醇联合阿霉素治疗局部晚期乳腺癌疗效显著,毒副作用少。
Objective To study the clinical effect of paclitaxel combined with doxorubicin in the treatment of locally advanced breast cancer. Methods One hundred and ten patients with locally advanced breast cancer admitted to Guangxi Wuzhou Workers Hospital from 2008 to 2015 were divided into group A and group B according to the random number table method, with 55 cases in each group. Patients in group A received paclitaxel plus doxorubicin, and patients in group B received capecitabine plus doxorubicin. The clinical effects and side effects of the two groups were compared. Results The total effective rate of treatment in group A was higher than that in group B, the difference was statistically significant (P <0.05). Two groups of patients after treatment, the incidence of side effects, the difference was not statistically significant (P> 0.05). Conclusion Paclitaxel combined with doxorubicin in the treatment of locally advanced breast cancer has obvious curative effect with few side effects.