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目的探讨术后131I治疗对甲状腺癌唾液腺功能与甲状腺球蛋白抗体(Tg Ab)影响。方法我院甲状腺癌手术后接受131I治疗患者79例,其中40例患者给予150 m Ci 131I治疗(150 m Ci组),39例给予80 m Ci8 131I治疗(80 m Ci组),比较两组唾液腺功能和Tg Ab水平的差异。结果 150 m Ci组治疗有效率稍高于80 m Ci组,但两组比较差异无统计学意义(P>0.05),150 m Ci组唾液初始p H值与唾液缓冲p H值明显高于80 m Ci组,唾液流率明显低于80 m Ci组,两组比较差异具有统计学意义(P<0.05),131I治疗后3、6个月,150 m Ci组平均Tg Ab水平明显低于80 m Ci组(P<0.05)。结论术后131I治疗对甲状腺癌临床疗效显著,其中低剂量131I治疗对唾液腺不良反应程度较低,而高剂量131I治疗有助于Tg Ab水平的降低。
Objective To investigate the effect of postoperative 131I treatment on thyroid gland function and thyroglobulin antibody (Tg Ab) in thyroid cancer. Methods A total of 79 131I-treated thyroid cancer patients undergoing thyroidectomy in our hospital were enrolled. Among them, 40 patients were treated with 150 m Ci 131I (150 m Ci group) and 39 patients were treated with 80 m Ci8 131I (80 m Ci group) Differences in function and Tg Ab levels. Results The effective rate of 150 m Ci group was slightly higher than that of 80 m Ci group, but there was no significant difference between the two groups (P> 0.05). The initial p H value and salivary buffer p H value of saliva in 150 m Ci group were significantly higher than 80 The mean salivary flow rate in m Ci group was significantly lower than that in 80 m Ci group (P <0.05). At 3 and 6 months after 131I treatment, the average Tg Ab level in 150 m Ci group was significantly lower than 80 m Ci group (P <0.05). Conclusions The clinical effect of 131I treatment on thyroid cancer is significant. Low-dose 131I treatment has a low adverse reaction to salivary gland, whereas high-dose 131I treatment can reduce the level of Tg Ab.