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Kokot和Kuska在1965年首先证实,肝胆疾病患者血清γ-谷氨酰转肽酶(γ-GTP)在电泳时出现多条区带.其后,有用纸、淀粉胶、琼脂糖凝胶、纤维凝胶(Cellogel)和聚丙烯酰胺电泳进行血清γ-GTP同工酶的分离,但对肝癌特异的一致的同工酶谱型则至今尚未报导.然而,有人已证实γ-GTP在胚胎肝和肝细胞瘤的活性较正常肝脏高,而且该酶在胚胎肝细胞内的亚细胞分布也不同于成人肝细胞.这些都提示了γ-GTP可能有癌胚特性,根据同工酶谱型可以更容易了解该酶的诊断意义.作者提供的方法可以检出肝细胞癌患者血清中特异的γ-GTP部份.
Kokot and Kuska first demonstrated in 1965 that serum G-glutamyl transpeptidase (γ-GTP) appeared in hepatocytes with multiple bands during electrophoresis, followed by paper, starch gel, agarose gel, Gel (Cellogel) and polyacrylamide electrophoresis for the separation of serum G-GTP isozymes, but for hepatocellular carcinoma specific isozymes profile has so far not been reported However, it has been confirmed γ-GTP in embryonic liver and Hepatoma activity is higher than normal liver, and the subcellular distribution of the enzyme in embryonic liver cells is also different from adult liver cells, which suggest that γ-GTP may have carcinoembryonic characteristics, according to the isozyme profile can be more Easy to understand the diagnostic significance of the enzyme.The method provided by the authors can detect serum of patients with hepatocellular carcinoma specific γ-GTP part.