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目的探讨不同程度的非酒精性脂肪肝患者的CD 4+CD 25+Foxp 3T细胞水平的变化。方法应用流式细胞术检测不同程度的非酒精性脂肪肝60例患者和20例健康体检者外周血的CD 4+CD 25+和CD 4+CD 25+Foxp 3的比例。结果非酒精性脂肪肝组外周血CD 4+CD 25+细胞占CD 4+的比例为8.53±1.64%,显著低于健康对照组的11.4±2.17%,P<0.01;且非酒精性脂肪肝患者病情越重,CD 4+CD 25+Foxp 3占CD 4+的比例越低(P<0.05)。结论非酒精性脂肪肝患者血清调节性T细胞百分数下降水平与脂肪肝程度呈正相关,CD 4+CD 25+Foxp 3T调节性T细胞减少可能打破了免疫耐受,参与了非酒精性脂肪肝患者的发病。
Objective To investigate the changes of CD 4 + CD 25 + Foxp 3T cells in patients with non-alcoholic fatty liver. Methods Flow cytometry was used to detect the ratio of CD 4 + CD 25+ and CD 4 + CD 25 + Foxp 3 in 60 patients with non-alcoholic fatty liver and 20 healthy controls. Results The ratio of CD 4 + CD 25+ cells to CD 4+ in non-alcoholic steatohepatitis group was 8.53 ± 1.64%, significantly lower than that in healthy control group (11.4 ± 2.17%, P <0.01), and non-alcoholic fatty liver The more severe the patients were, the lower the proportion of CD 4 + CD 25 + Foxp 3 to CD 4+ (P <0.05). Conclusions The decrease of the percentage of serum regulatory T cells in patients with non-alcoholic fatty liver is positively correlated with the degree of fatty liver. The decrease of CD4 + CD25 + Foxp 3T regulatory T cells may break the immune tolerance and participate in the treatment of non-alcoholic fatty liver disease The incidence.