【摘 要】
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Since being developed approximately 20 years ago, high throughput screening (HTS) has become one of the key techniques used in drug discovery[1]. However, three
【机 构】
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Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beiji
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Since being developed approximately 20 years ago, high throughput screening (HTS) has become one of the key techniques used in drug discovery[1]. However, three main problems are recognized with the use of HTS; namely, with the compound library, drug targets, and assay methods. Until now, the compound library has evolved based on the techniques of combinatorial chemistry and mode phytochemistry. Several functional proteins have emerged following the advance of genomics and proteomics. However,although many functional proteins have been discovered recently, they are not, as sometimes claimed, real drug targets;at best, they might be potential drug targets. The ideal targets selected for drug screening should qualify as drug targets[2]. The selection of targets for drug screening is a crucial procedure in drug screening.
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