Strategy of Systems Biology for Visualizing the “Black Box” of Traditional Chinese Medicine

来源 :世界中医药杂志(英文版) | 被引量 : 0次 | 上传用户:chenming000
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Traditional Chinese medicine?(TCM) has been practiced for thousands of years in China. TCM formula, usually composed of several or even dozens of herbal medicines, is the main form of TCM practicing, which is extremely complex due to multiple components and therapeutic targets, especially the characteristics of formula compatibility. Thus, it is an enormous challenge for the modernization of TCM. Systems biology is a strategy for investigating the complex interactions between genes, mRNA, proteins, and metabolites by using integrated omics approaches. In recent years, systems biology has been increasingly adopted in TCM study. This review comprehensively summarized status of syndrome and application of TCM formulae in clinical and preclinical studies and discussed the advances of systems biology in TCM research. Then, a “Disease?Syndrome?Formulae?Effect” strategy was proposed for TCM research. Combination of systems biology and “Disease?Syndrome?Formulae?Effect” strategy provided a novel approach to understand the complex interactions among biological systems, drugs, and complex diseases from a network perspective, thus facilitating the modernization of TCM. The objective of this manuscript is to provide comprehensive and up?to?date review on the application of systems biology in TCM research, as well as the perspective of TCM modernization with systems biology.
其他文献
课堂教学艺术就是教师在课堂上遵照教学法则和美学尺度的要求,灵活运用语言、表情、动作、心理活动、图像组织、调控等手段,充分发挥教学情感的功能,为取得最佳教学效果而施
当下数学课堂,以知识传递为教学目标的现象依然存在,在这种价值导向下,数学教学最为突出的局限在于对教学中“人”的忽视,带来的结果就是教师缺乏用整体综合的思维方式,对概
小学高年级语文教学,教师往往重视篇章教学,而忽视词语的有效教学.然而,很多文章中的关键词语恰恰是文章理解的关键所在.教师应抓住关键点,用幽默的方式引导学生将词语放入具
本文基于学习性评价理论的内涵,以《角的初步认识》教学为例,从构建学历案、设置学程、设定评价标准等方面,将多维化的评价活动嵌入整个教学活动中,从而探索学习性评价促进学
从三年级开始,统编版语文教材在每册教材中都设置了一个习作单元,是一种新的单元编排方式,是新教材编写体例的一个创新.教师要更好地研透教材,把握习作单元教学的功能定位,明
说课是一种独特的教学实践活动,优质的说课亦是一种教学艺术.通过外在看“说”、内在看“理”两方面可以有效地理解和分析一堂说课的质量.优秀的说课,“说”要说得有滋有味儿
数学核心素养,其核心是人的发展,旨在培养全面发展的人.而全面发展的人必定是自信的能充分表达自己想法和观点的人.表达能力的培养是数学课上发展学生思维品质,提升学生数学
三角形是学习平面图形知识的起点,准确把握图形特征、迅速形成相关概念对学生学好三角形乃至今后所有的几何课程都至关重要.本文以《三角形的认识》为例,详细阐述比较引导和
目的:观察慢性心力衰竭患者中心肌损伤标志物的变化,探讨心肌损伤标志物与慢性心力衰竭患者的关系。方法:根据纳入标准和排除标准,将我院288例住院病人,分为心衰组和对照组,
周宗岱中国画展时间:2007年10月22日—25日地点:中国国家画院美术馆主办:中国国家画院湖南省文学艺术界联合会承办:中国国家画院美术馆协办:中国国家画院艺术交流中心湖南省