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目的通过对我院2009年1至12月收集的167例药品不良反应信息汇总,分析药品不良反应(ADR)的发生情况、发生特点及相关因素。方法采用病例回顾性研究的方法 ,总结不良反应发生状况。结果 167例ADR报告中50岁以上人群所占比例最大,女性患者发生ADR的概率明显增加,男女比例为1:1.7;涉及的药品中抗生素类药物、中成药和中药注射剂、心脑血管类药物ADR发生率高;ADR表现中皮肤及其附件损害发生率高。结论抗生素类药物、中药制剂是ADR监测的重点药物,应加强特殊人群、静脉给药方式和重点药物的ADR监测,提高合理用药水平,减少药源性疾病的发生。
Objective To analyze the incidence, occurrence characteristics and related factors of adverse drug reactions (ADRs) in 167 cases of ADR collected in our hospital from January to December in 2009. Methods The case retrospective study of methods to summarize the incidence of adverse reactions. Results 167 cases of ADR report the largest proportion of people over the age of 50, the incidence of ADR in female patients increased significantly, the male to female ratio was 1: 1.7; involved in the antibiotics drugs, proprietary Chinese medicines and Chinese medicine injection, cardiovascular and cerebrovascular drugs ADR high incidence; ADR performance in the skin and its accessories high incidence of damage. Conclusions Antibiotics and traditional Chinese medicine preparations are the key drugs for ADR monitoring. We should strengthen the monitoring of ADR of special populations, intravenous administration methods and key drugs to improve the rational use of drugs and reduce the occurrence of drug-induced diseases.