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目的探讨尘肺结核菌阳初治患者根据尘肺分期使用不同疗程化疗方案的近远期疗效。方法按尘肺分期及病灶范围分为4组(A_1、A_2、B_1、B_2)给予不同的化疗方案,全程督导治疗结束并随访5年。考核痰菌的阴转率、复阳率,并进行各组间比较。结果4组病例化疗疗程结束痰菌阴转率达到100%,随访5年期间痰菌复阳率分别为17.4%、4.3%、22.5%、5.0%。结论A_2组方案3HRZS(E)/6HRZ/9HRE适用于Ⅰ～Ⅱ期尘肺结核,B_2组方案3HRZS(E)/9HRZ/12HRE适用于Ⅲ期尘肺结核,对该组方案的远期疗效满意。
Objective To explore the short-term and long-term effects of different courses of chemotherapy in pneumoconiosis patients with positive pneumoconiosis treated with pneumoconiosis. Methods The patients were divided into 4 groups (A_1, A_2, B_1, B_2) according to the stage of pneumoconiosis and the extent of the lesion. Different chemotherapy regimens were given. The whole course of supervising treatment was completed and followed up for 5 years. Examination of sputum negative conversion rate, complex Yang rate, and compared between groups. Results The sputum negative conversion rate reached 100% at the end of chemotherapy in 4 groups, and the sputum positive rates were 17.4%, 4.3%, 22.5% and 5.0% respectively during the follow-up period of 5 years. Conclusion The 3HRZS (E) / 6HRZ / 9HRE regimen in group A_2 is suitable for patients with stage Ⅰ ~ Ⅱ pneumoconiosis. The 3HRZS (E) / 9HRZ / 12HRE regimen in group B_2 is suitable for stage Ⅲ pneumoconiosis with satisfactory long - term outcome.