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目的针对内蒙古蒙古族人群的ADRB1基因G1165C位点、GNB3基因C825T位点进行多因素分析,探讨ADRB1基因G1165C位点、GNB3基因C825T位点与蒙古族人群肥胖的相关性。方法采用Sequenom系统检测183例蒙古族健康人和90例肥胖患者的ADRB1基因G1165C位点、GNB3基因C825T位点的分布特点。结果 (1)肥胖组和对照组的临床特征经比较2组在年龄、饮酒、高血压家族史方面存在统计学差异,P<0.05。(2)基因型及等位基因频率分布比较:两组各基因型频率及等位基因频率分布符合Hardy-Weinberg平衡,达到遗传平衡,具有群体代表性。2组在ADRB1基因G1165C位点、GNB3基因C825T位点基因型及等位基因频率比较差异无统计学意义(P>0.05)。(3)经Logistic逐步回归分析后结果为2组基因型在肥胖的发病过程中无交互作用(P>0.05)。结论 ADRB1基因G1165C位点、GNB3基因C825T位点可能不是蒙古族人群患肥胖症的易感基因。
Objective To investigate the relationship between the G1165C locus of ADRB1 gene and the C825T locus of GNB3 gene in Mongolian population of Inner Mongolia to investigate the relationship between G1165C locus of ADRB1 gene and C825T locus of GNB3 gene and obesity in Mongolian population. Methods The distribution features of G1165C site and GNB3 gene C825T site of ADRB1 gene in 183 Mongolian healthy subjects and 90 obese patients were detected by Sequenom system. Results (1) The clinical features of obesity group and control group were statistically different between the two groups in terms of age, alcohol consumption and family history of hypertension (P <0.05). (2) Comparison of genotype and allele frequency distribution: The genotype frequency and allele frequency distribution of two groups accord with Hardy-Weinberg equilibrium, reach the genetic balance, and have group representative. There was no significant difference in genotype and allele frequencies of GNB3 gene C825T between two groups at G1165C site of ADRB1 (P> 0.05). (3) Logistic stepwise regression analysis showed that there was no interaction between the two genotypes in the pathogenesis of obesity (P> 0.05). Conclusion G1165C site of ADRB1 gene and C825T site of GNB3 gene may not be susceptible genes of Mongolian population.