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目的:检测口腔鳞癌组织中3p14.2区D3S1300位点丢失情况,为新的抑癌基因定位提供依据。方法:应用聚合酶链反应(PCR)技术以D3S1300位点微卫星多态为遗传标记,检测口腔鳞癌组织中该位点的杂合性丢失(Losofheterozygosity,LOH)状况。结果:22例口腔鳞癌17例提供信息,7例出现杂合性丢失,LOH率为41%(7/17),有2例出现微卫星的不稳定性。结论:3p14.2区D3S1300位点杂合性丢失可能与口腔鳞癌的发生发展相关,提示该区域可能存在口腔鳞癌的抑癌基因,该区的错配修复基因突变可能是口腔鳞癌发生的一个新机理
Objective: To detect the loss of D3S1300 in 3p14.2 in oral squamous cell carcinoma and provide evidence for the new tumor suppressor gene mapping. METHODS: Polymerase chain reaction (PCR) was used to detect the loss of heterozygosity (LOH) in the oral squamous cell carcinoma (SCC) tissue using D3S1300 locus microsatellite polymorphism. RESULTS: Twenty-six cases of oral squamous cell carcinoma provided information, 7 cases showed loss of heterozygosity, the LOH rate was 41% (7/17), and 2 cases showed microsatellite instability. Conclusion: Loss of heterozygosity at D3S1300 locus in 3p14.2 may be associated with the development of oral squamous cell carcinoma, suggesting that there may be an anti-oncogene in oral squamous cell carcinoma in this region. Mutations in the mismatch repair gene in this region may be the occurrence of oral squamous cell carcinoma. A new mechanism