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目的:初步探讨复方苦参注射液联合体部伽玛刀治疗原发性肝癌的临床疗效。方法:收集78例原发性肝癌患者作为研究对象,随机分为单纯伽玛刀治疗组(39例),综合治疗组(39例)。观察患者治疗后的近期肿瘤局部控制率、生活质量改善率、疼痛改善率、AFP的下降程度以及对肝功能、WBC的影响程度。结果:综合治疗组患者的近期肿瘤局部控制率、生活质量改善率、疼痛改善率、AFP的下降程度均优于对照组,而对肝功能、WBC的影响程度也小于对照组,差异有统计学意义(P<0.05)。结论:复方苦参注射液联合体部伽玛刀治疗原发性肝癌可有效地提高肿瘤局部控制率,改善患者的生活质量及疼痛,降低伽玛刀治疗后的副反应。
Objective: To investigate the clinical efficacy of Compound Kushen Injection combined with Gamma Knife in the treatment of primary liver cancer. Methods: A total of 78 primary hepatocellular carcinoma patients were collected and randomly divided into simple gamma knife treatment group (39 cases) and comprehensive treatment group (39 cases). To observe the recent local tumor control rate, quality of life improvement rate, the improvement rate of pain, the decline of AFP and the degree of influence on liver function and WBC in patients after treatment. Results: The recent local tumor control rate, quality of life improvement rate, pain relief rate and AFP decrease in the comprehensive treatment group were better than those in the control group, but the effects on the liver function and WBC were also less than those in the control group Significance (P <0.05). Conclusion: Compound Kushen injection combined with gamma knife treatment of primary liver cancer can effectively improve the local control rate of tumor, improve the quality of life and pain of patients and reduce side effects after gamma knife treatment.