前言治疗的目的是在感染部位达到适当的抗菌活性,就化脓性支气管炎而论,支气管分泌物与其感染部位密切接触,因而说明了抗生素在其分泌物中的浓度对治疗的有效性起着决定性的作用。在一些与呼吸道渗出液细菌学有关的临床效果的研究中证明,其治疗效果取决于在痰中的抗菌药物浓度,要比血中的药物浓度更为重要。现有文献证明,虽然血中抗菌药物浓度达到了足够的水平,但由于在痰中的浓度太低,却不能杀灭致病菌,而使治疗失效。已经报告的氨基糖苷类抗生素通过血液-支气 Introduction The purpose of treatment is to achieve appropriate antibacterial activity at the site of infection. In the case of purulent bronchitis, bronchial secretions are in intimate contact with the site of infection, thus demonstrating that the concentration of antibiotics in their secretions is decisive for the effectiveness of the treatment Role. In some studies of the bacteriological effects of airway exudate, it has been demonstrated that the therapeutic effect depends on the concentration of antimicrobials in the sputum, which is more important than the drug concentration in the blood. The existing literature proves that, although the blood antimicrobial concentration reached a sufficient level, but due to the concentration in the sputum is too low, but can not kill pathogens, leaving the treatment failure. Aminoglycoside antibiotics have been reported to pass through the blood-bronchi