论文部分内容阅读
目的初步了解佛山市流动人口肺结核耐药情况,分析其影响因素,为佛山流动人口结核病防治规划的制定提供依据。方法佛山市2008-2012年确诊登记的773例流动人口痰培养阳性肺结核患者作为研究对象,对所有分离培养阳性菌株进行菌型鉴定和利福平(RFP)、异烟肼(INH)、链霉素(Sm)、乙胺丁醇(EMB)4种一线药物敏感性试验;通过调查问卷收集相关信息,分析流动人口耐药结核病流行状况和主要影响因素。结果 773例流动人口肺结核患者,结核分枝杆菌总耐药率:21.22%(164/773),初治涂阳患者耐药率是:18.08%(117/647),复治涂阳患者耐药率:37.30%(47/126)。总耐多药率:6.99%(54/773),初治涂阳患者耐多药率是4.48%(29/647),复治涂阳患者耐多药率:19.84%(25/126),一线抗结核药物耐药率顺位是:Sm(18.50%)>INH(15.14%)>RFP(11.77%)>EMB(6.34%);多因素logistic回归分析显示,复治涂阳患者与耐药性之间存在相关性(OR=9.34;95%CI:8.53~10.14,P<0.01),差异有统计学意义。结论佛山市流动人口肺结核总耐药率和多耐药率较高,复治是流动人口肺结核出现耐药主要影响因素。
Objective To understand the prevalence of pulmonary tuberculosis in floating population in Foshan City and analyze the influencing factors, so as to provide the basis for the formulation of the prevention and control program for floating population in Foshan. Methods A total of 773 sputum culture positive pulmonary tuberculosis patients diagnosed and registered from 2008 to 2012 in Foshan City were selected as the research objects. All strains isolated and cultured were identified for their mycobacterial type and identified as rifampin (RFP), isoniazid (INH), streptomycin (Sm) and ethambutol (EMB). Through questionnaires, relevant information was collected to analyze the prevalence and main influencing factors of drug-resistant TB in floating population. Results The total drug resistance rate of tuberculosis in 773 floating population was 21.22% (164/773). The drug resistance rate of newly smear positive patients was 18.08% (117/647) Rate: 37.30% (47/126). The rate of MDR was 6.99% (54/773). The rate of MDR was 4.48% (29/647) in smear-positive patients and 19.84% (25/126) in smear-positive patients. The first-line antituberculosis drug resistance rates were: Sm (18.50%)> INH (15.14%)> RFP (11.77%)> EMB (6.34%); multivariate logistic regression analysis showed that the drug- (OR = 9.34; 95% CI: 8.53 ~ 10.14, P <0.01), the difference was statistically significant. Conclusion The total resistance rate and multi-drug resistance rate of pulmonary tuberculosis in floating population in Foshan City are higher. Rehabilitation and treatment are the main influencing factors of TB resistance in floating population.