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目的探讨胃癌组织中血管表皮生长因子C(VEGF C)表达与血管和淋巴管密度及肿瘤淋巴转移的关系。方法采用免疫组化SP法检测 6 8例胃癌组织中VEGF C、CD 31及淋巴管内皮标记物VEGFR 3,计算VEGF C表达的阳性率及肿瘤微血管和微淋巴管密度。结果淋巴结阳性组中VEGF C阳性率 (70 % )显著高于淋巴结阴性组 (30 % ) ,P <0 0 5 ;与VEGF C阴性组 (2 4 4±2 1 )比较 ,VEGF C阳性组淋巴管密度 (2 9 6± 3 0 )明显增高 ,P <0 0 5 ,而微血管密度在两组之间差异无显著意义 ,P >0 0 5 ;与淋巴结阴性组比较 ,在淋巴结转移阳性组淋巴管密度 (31 6± 2 1 )、微血管密度 (4 0 2± 2 3)均有显著提高 ,P <0 0 5。结论VEGF C主要通过调节胃癌组织微淋巴管的生成而影响胃癌淋巴结转移 ;微淋巴管密度与微血管密度均为胃癌淋巴结转移的重要影响因素
Objective To investigate the relationship between the expression of vascular endothelial growth factor C (VEGF C) and the density of blood vessels and lymphatic vessels and lymphatic metastasis in gastric cancer. Methods Immunohistochemical SP method was used to detect VEGF C, CD 31 and VEGFR 3, a marker of lymphatic endothelial cell marker, in 68 gastric cancer tissues. The positive rate of VEGF C expression and the density of tumor microvessel and lymphatic vessel were calculated. Results The positive rate of VEGF C in lymph node positive group (70%) was significantly higher than that in lymph node negative group (30%) (P <0.05). Compared with VEGF C negative group (24.4 ± 21) The tube density (296 ± 30) was significantly higher, P <0 05, while the microvessel density was not significantly different between the two groups (P> 0.05). Compared with the lymph node-negative group, The tube density (31 6 ± 2 1), microvessel density (4 0 2 ± 2 3) were significantly increased, P <0 05. Conclusion VEGF C mainly affects lymphatic metastasis of gastric cancer by regulating the production of lymphatic vessels in gastric cancer. Lymphatic vessel density and microvessel density are both important factors in lymph node metastasis of gastric cancer