多发性原发性肺癌的诊断在1955年由美国纽约纪念医院首次提出,其后20年中该院治疗的原发性肺癌5,163例中,此种病人共有50例,占0.97%。50例中38例男性,12例女性。49例是两个癌肿,1例是三个癌肿。肿瘤同期出现的有18例,后期出现的有32例,时间间隔4个月～16年,平均间隔57个月。在间隔两年以上的7例中,都有一个肿瘤是X线隐匿性而经细胞学检查发现的。66%组织学上相同,其中79%是上皮样或鳞癌;34%组织学不一致,其中70%是鳞癌和其它类型併存的。33例 The diagnosis of multiple primary lung cancer was first proposed by the New York Memorial Hospital in the United States in 1955. Of the 5,163 primary lung cancer patients treated in the hospital for the next 20 years, 50 patients had this type, accounting for 0.97%. Of the 50 cases, 38 were males and 12 were females. 49 cases were two cancers and 1 case was three cancers. There were 18 cases of tumors in the same period and 32 cases in the later period. The time interval was 4 months to 16 years with an average interval of 57 months. In 7 cases more than two years apart, there was a tumor that was discovered by occult X-ray cytology. 66% were histologically identical, of which 79% were epithelioid or squamous cell carcinoma; 34% were histologically inconsistent, 70% of which were squamous cell carcinoma and other types. 33 cases