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目的:探讨米非司酮配伍米索前列醇用于10～14周妊娠的临床应用效果。方法:对停经10～14周要求终止妊娠且无用药禁忌证的孕妇采用口服米非司酮和阴道后穹窿放置米索前列醇进行药物流产后清宫,观察胚胎排出情况及时间、腹痛情况。结果:停经10～14周服用药物流产后,胚胎完整排出率为64.7%,部分排出率为20.30%,失败率3.24%;完全流产者胚胎排出时间为服药后(5.20±2.58)h,不完全流产者胚胎排出时间为服药后(12.11±4.27)h。所有观察对象平均出血持续时间(8.38±2.65)d;完全流产者72 h阴道出血量(52.94±11.03)ml;不完全流产者72 h阴道出血量(66.32±16.15)ml;流产失败者72 h阴道出血量(26.94±6.25)mL。结论:米非司酮配伍米索前列醇用于终止10～14周妊娠具有效果好,成功率高等优点;在严密、谨慎应用的情况下,其安全、方便、损伤小,患者易于接受。
Objective: To investigate the clinical effect of mifepristone and misoprostol for 10-14 weeks gestation. Methods: Pregnant women who required termination of pregnancy and no medication contraindications after 10-14 weeks’ menopause were treated with oral administration of misoprostol and vaginal posterior fornix for abortion, and observed the status of embryo discharge, time and abdominal pain. Results: After taking medical abortion 10 to 14 weeks after menopause, the complete embryo discharge rate was 64.7%, the partial discharge rate was 20.30% and the failure rate was 3.24%. The embryo excretion time of complete abortion was 5.20 ± 2.58 h Abortion embryos were discharged after taking the drug (12.11 ± 4.27) h. The mean duration of bleeding in all subjects was (8.38 ± 2.65) d, the amount of vaginal bleeding in 72 h after complete abortion (52.94 ± 11.03) ml, the amount of vaginal bleeding in 72 h (66.32 ± 16.15) ml in incomplete abortion, Vaginal bleeding volume (26.94 ± 6.25) mL. Conclusion: Mifepristone combined with misoprostol has the advantages of good effect and high success rate in termination of pregnancy of 10 to 14 weeks. It is safe, convenient and less damaging in patients with strict and cautious application. It is easy for patients to accept.