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血管假性血友病因子（ｖＷＦ）与血小板糖蛋白Ｉｂ（ＧＰＩｂ）的相互作用在止血过程和血栓形成的早期阶段起着关键作用， 而蛇毒中含有的一些蛋白能特异性地结合并调控两者之间的相互作用。本文从分子生物学水平上概述了近年来调控ｖＷＦ和ＧＰＩｂ 的蛇毒蛋白的研究进展， 包括调控ｖＷＦ的美洲矛头蝮毒蛋白（ｂｏｔｒｏｃｅｔｉｎ）、鼓腹巨蝰毒蛋白（ｂｉｔｉｓｃｅｔｉｎ）及调控ＧＰＩｂ 的白唇竹叶青聚集蛋白Ｂ（ａｌｂｏａｇｇｒｅｇｉｎ－Ｂ）、锯鳞蝰毒蛋白（ｅｃｈｉｃｅｔｉｎ）、美洲矛头腹ＧＰＩＢ－ＢＰ（ｊａｒａｒａｃａＧＰＩｂ－ＢＰ）、西部菱斑响尾蛇蛋白（ｃｒｏｔａｌｉｎ）等，从而为新型抗血栓药物的开发和蛇毒的临床应用提供了理论基础。
The interaction of vWF with platelet glycoprotein Ib (GPIb) plays a key role in the hemostasis process and in the early stages of thrombosis, whereas some proteins contained in snake venom specifically bind and regulate two Interaction between people. This review summarizes recent advances in the regulation of vWF and GPIb in snake venom proteins from the molecular biology level, including botrocetin, bitiscetin regulating vWF, Alboaggregin-B, echicetin, GPIB-BP (jararacaGPIb-BP) and crotalin in the west of the United States, thus providing a new method for the development of new antithrombotic drugs and snake venom The clinical application provides the theoretical basis.