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目的探讨小鼠肺组织内5-脂氧酶(5-LO)与呼吸道感染的关系。方法采用免疫组织化学方法检测24只小鼠肺组织内5-LO的表达。结果感染组小鼠5-LO阳性强度比未感染组高;治疗组小鼠5-LO的表达强度降低。结论小鼠肺组织5-LO的表达强度,对临床及科研中肺感染疗效的评价有一定参考价值。
Objective To investigate the relationship between 5-lipoxygenase (5-LO) and respiratory tract infection in mouse lung tissue. Methods Immunohistochemistry was used to detect the expression of 5-LO in the lung tissue of 24 mice. Results The positive rate of 5-LO in the infected group was higher than that in the non-infected group. The expression of 5-LO in the treated group was decreased. Conclusions The expression of 5-LO in lung tissue of mice has certain reference value for evaluating the curative effect of lung infection in clinic and research.