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目的本文探讨北虫草提取物对大鼠附性腺和血清睾酮的调节作用,为利用北虫草的营养价值提供科学依据。方法实验分4组,对照组、多鞭精组、给药组(低、高剂量组),每组大鼠12只。采用组织器官增重法观察大鼠附性腺的重量(mg·kg-1),放射免疫分析法测定血清睾酮含量(fmol.L-1)。结果低、高剂量组大鼠包皮腺重量为(27.04±2.33)、(31.38±7.42)、精液囊和提肛肌重量分别为(25.81±5.94)、(18.30±4.11)与(29.52±6.82)、(26.01±5.17)、高剂量组大鼠前列腺重量为(13.51±3.71)均明显高于对照组,有显著性差异(P<0.05)。多鞭精实验组大鼠附性腺重量为(31.52±2.01)、(9.12±2.83)、(19.74±6.19)和(18.59±3.56)均高于对照组,有显著性差异(P<0.05)。高剂量组大鼠前列腺、精液囊和提肛肌重量高于多鞭精实验组,有显著性差异(P<0.05)。低与高剂量组睾酮含量为(2883.07±210.12)和(3167.23±251.69)高于对照组与多鞭精组,有显著性差异(P<0.05)。结论北虫草提取物具有促进大鼠附性腺发育和兴奋雄激素分泌的功能。
Objective To investigate the regulatory effect of Cordyceps militaris extract on rat accessory glands and serum testosterone, and provide scientific basis for the nutritional value of Cordyceps militaris. Methods The experiment was divided into 4 groups: control group, multi-whiplash group, and administration group (low and high dose groups). There were 12 rats in each group. The weight of the attached glands (mg·kg-1) was measured using a tissue-organ weight method, and the serum testosterone content (fmol.L-1) was determined by radioimmunoassay. Results The weight of premedical glands in the low-dose and high-dose groups was (27.04±2.33), (31.38±7.42), the sac and levator ani muscle weights were (25.81±5.94), (18.30±4.11), and (29.52±6.82), respectively. The prostate weights of (26.01±5.17) and high-dose groups were significantly higher than those of the control group (13.51±3.71), with significant differences (P<0.05). The weight of the accessory gland in the multi-whiplash test group was (31.52±2.01), (9.12±2.83), (19.74±6.19), and (18.59±3.56) were higher than those in the control group, with significant differences (P<0.05). The weight of the prostate, seminal vesicle and levator ani muscle in the high-dose group was higher than that in the multi-whiplash experimental group, with significant differences (P<0.05). The levels of testosterone in the low- and high-dose groups were (2883.07±210.12) and (3167.23±251.69) higher than those in the control group and the multi-whiplash group, with significant differences (P<0.05). Conclusion The Cordyceps extract has the function of promoting the development of gonadal glands and excitatory androgen secretion in rats.