Powder metallurgy(PM) Ti–22Al–24Nb–0.5Mo(at.%) alloys were prepared by hot isostatic pressing. In order to study the feasibility of PM + ring rolling combined process for preparing Ti_2AlNb rings, thermal mechanical simulation tests of PM Ti_2AlNb alloys were conducted and two rectangular PM rings(150 mm in height, 75 mm in thickness,350 mm in external diameter) were rolled as a validation experiment. Experimental results show that the flow stress of Ti_2AlNb alloys exhibited a significant drop at the very beginning of the deformation(true strain0.1), and became stable with the increase in strain. Stress instability phenomenon of PM Ti_2AlNb alloys was more obvious than that of wrought alloy. Flow stress fluctuation at the initial stage of deformation is related to phase transition of Ti_2AlNb alloys which strongly depends on heat treatment and thermal mechanical deformation process. Processing windows during initial stage of ring rolling process is very crucial. A sound PM Ti_2AlNb rectangular ring blank(height = 150 mm, thickness = 30 mm, external diameter = 750 mm) was successfully rolled in two passes by using the improved heat preservation method and optimized rolling parameters. Tensile properties of PM Ti_2AlNb alloy were improved, and the porosity was reduced after ring rolling. Powder metallurgy (PM) Ti-22Al-24Nb-0.5Mo (at.%) Alloys were prepared by hot isostatic pressing. In order to study the feasibility of PM + ring rolling combined process for preparing Ti_2AlNb rings, thermal mechanical simulation tests of PM Ti_2AlNb alloys were conducted and two rectangular PM rings (150 mm in height, 75 mm in thickness, 350 mm in external diameter) were rolled as a validation experiment. Experimental results show that the flow stress of Ti_2AlNb alloys exhibited a significant drop at the very beginning of the deformation (true strain 0.1), and became stable with the increase in strain. Stress instability phenomenon of PM Ti_2AlNb alloys was more obvious than that of wrought alloy. Flow stress fluctuation at the initial stage of deformation is related to phase transition of Ti_2AlNb alloys which strongly depends on heat treatment and thermal mechanical deformation process. Processing windows during initial stage of ring rolling process is very crucial. A sound PM Ti_ 2AlNb rectangular ring blank (height = 150 mm, thickness = 30 mm, external diameter = 750 mm) was successfully rolled in two passes by using the improved heat preservation method and optimized rolling parameters. Tensile properties of PM Ti_2AlNb alloy were improved, and the porosity was reduced after ring rolling.