美沙酮,最早在二战期间由德国研制和合成,当时主要用于镇痛。20世纪60年代美国科学家最先提出“美沙酮维持”的概念,将美沙酮用于替代治疗阿片类(海洛因)依赖。美沙酮同时具有理想的替代维持治疗药的三个特点:一是作用时间比较长;二是药物滥用潜力比较低;三是可以口服给药,如今已成为全球阿片类物质依赖维持疗法中应用最为广泛、最有效的方式之一。一、天河走上美沙酮维持治疗之路2003年我国卫生部、公安部、食药监局联 Methadone, first developed and synthesized by Germany during World War II, was mainly used for analgesia. In the 1960s, American scientists first proposed the concept of “methadone maintenance” and used methadone as an alternative to opioid (heroin) dependence. Methadone also has three characteristics that make it an ideal alternative to maintenance medicine: one is its longer duration of action; the other is its potential for abuse; the third is oral administration that has now become the most widely used global opioid dependence maintenance therapy One of the most effective ways. First, the Milky Way onto the road to methadone maintenance treatment 2003 China's Ministry of Health, Ministry of Public Security, Food and Drug Administration