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目的探讨双歧杆菌预防早产儿坏死性小肠结肠炎(NEC)的疗效。方法随机分成试验组和对照组,对照组给予常规治疗,试验组在对照组基础上给予双歧杆菌治疗。观察两组不同胎龄和不同出生体重早产儿NEC患病率、治疗前后肠道各菌群变化的差异。结果 (1)试验组NEC总发生率显著低于对照组,差异有统计学意义(P<0.01);(2)试验组出生体重<1 500 g早产儿NEC发生率显著低于对照组,差异有统计学意义(P<0.05);(3)治疗后试验组细菌总数、球菌总数及杆菌总数上升幅度显著大于对照组,差异均有统计学意义(P<0.01);治疗后试验组杆球菌比值较对照组显著下降,差异有统计学意义(P<0.01)。结论双歧杆菌可有效预防早产儿坏死性小肠结肠炎。
Objective To investigate the efficacy of Bifidobacterium in the prevention of necrotizing enterocolitis (NEC) in preterm infants. Methods Randomly divided into experimental group and control group. The control group was given routine treatment. The experimental group was treated with Bifidobacterium on the basis of the control group. The prevalence of NEC in two groups of preterm infants with different gestational ages and different birth weights was observed. The changes of intestinal flora before and after treatment were observed. Results (1) The incidence of NEC in experimental group was significantly lower than that in control group (P <0.01); (2) The incidence of NEC in preterm infants with birth weight <1 500 g in experimental group was significantly lower than that in control group (P <0.05). (3) After treatment, the total number of bacteria, the total number of bacteria and the total number of bacilli increased significantly in the experimental group after treatment compared with the control group, the difference was statistically significant (P <0.01) The ratio was significantly lower than the control group, the difference was statistically significant (P <0.01). Conclusion Bifidobacterium can effectively prevent necrotizing enterocolitis in preterm infants.