论文部分内容阅读
Aluminum (Al) is the most abundant metal in the Earth's crust and is widely used in everyday life and industry. Al is neurotoxic to mammals. Epidemiological studies have confirmed the positive relationship between an increased environmental Al concentration and cognitive impairment[1]. Hippocampal long-term potentiation (LTP) has been widely used as a neuronal model of synaptic plasticity in experiments designed to elucidate the synaptic mechanisms involved in the loss of learning and memory[2]. The alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptor (AMPAR), a major glutamate-gated ion channel in the mammalian central nervous system, plays important roles in synaptic transmission, synaptic plasticity such as LTP, and learning and memory cognitive function of the brain. LTP typically results from an increased concentration of AMPARs at the postsynaptic membrane surface[3].