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目的：研究肝硬化严重程度与胰岛素敏感性指数之关系。方法：按child-pugh记分法，对48例肝硬化分A、B、C三级，用葡萄糖氧化酶法及放免法分别测定空腹及餐后2小时静脉血糖及胰岛素、C肽水平，计算胰岛素敏感性指数。结果：肝硬化糖代谢异常发生率明显增高(p＜0.01)。三级肝硬化之间胰岛素敏感性指数有显著差异(p＜0.01)。结论：肝硬化患者的child-pugh分级与胰岛素敏感性指数呈负相关，随肝硬化程度加重胰岛素抵抗越明显。
Objective: To study the relationship between the severity of liver cirrhosis and insulin sensitivity index. Methods: According to the child-pugh score method, 48 cases of liver cirrhosis were divided into A, B and C levels. Glucose oxidase and radioimmunoassay were used to measure fasting and postprandial 2-hour venous blood glucose, insulin and C-peptide levels, Sensitivity index. Results: The incidence of liver cirrhosis with abnormal glucose metabolism was significantly increased (p <0.01). There was a significant difference in insulin sensitivity index between grade 3 cirrhosis (p <0.01). Conclusion: There is a negative correlation between the child-pugh classification and insulin sensitivity index in patients with cirrhosis. The more obvious the insulin resistance is with the degree of cirrhosis.