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由3,5-二碘水杨醛和2,6-二氨基吡啶反应合成了席夫碱配体,将其与4种过渡金属硝酸盐反应生成相应的配合物,通过元素分析、电子光谱、红外光谱、TG-DTA及摩尔电导率确定配合物的结构和组成为[M(NO3)L].H2O,由Gaussian03程序对其进行了优化计算,给出了配合物的主要键参数。通过紫外吸收光谱、荧光发射光谱、粘度法、稳态荧光猝灭方法及其与溴化乙锭(EB)的竞争实验研究了Co(Ⅱ)配合物与小牛胸腺DNA(ct-DNA)的作用情况,结果显示,配合物与ct-DNA作用时,其紫外吸收产生明显减色效应,荧光强度增强;EB-DNA体系的荧光强度随配合物的加入迅速减弱;在ct-DNA存在下,配合物的荧光强度随猝灭剂K4[Fe(CN)6]体积的增加变化较为缓慢;配合物的加入使ct-DNA的粘度增加;这些结果表明配合物是以插入方式与ct-DNA结合的。打孔法研究配合物的抗菌活性结果表明,配合物对藤黄微球菌(M.luteus)有良好的抑制作用。
Schiff base ligand was synthesized from 3,5-diiodosalicylaldehyde and 2,6-diaminopyridine and reacted with four kinds of transition metal nitrates to form the corresponding complexes. By elemental analysis, electron spectroscopy, The structure and composition of the complex were determined by FT-IR, TG-DTA and molar conductivity [M (NO3) L] .H2O. The main bond parameters of the complex were given by Gaussian03 program. The effects of Co (Ⅱ) complex and calf thymus DNA (ct-DNA) were studied by ultraviolet absorption spectroscopy, fluorescence emission spectroscopy, viscometry, steady state fluorescence quenching and their competition with ethidium bromide The results showed that the UV-absorbance of the complex decreased obviously when the complex was reacted with ct-DNA, and the fluorescence intensity of the complex increased. The fluorescence intensity of the EB-DNA system rapidly decreased with the addition of the complex. In the presence of ct-DNA, The fluorescence intensity of the complex changed slowly with the increase of the volume of the quencher K4 [Fe (CN) 6]. The addition of the complex increased the viscosity of ct-DNA. These results indicated that the complex was inserted into ct-DNA of. The antibacterial activity of the complex was studied by the punching method. The results showed that the complex had a good inhibitory effect on M.luteus.