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骨折、骨质疏松和骨密度降低所造成的健康危害和经济费用相当高。当前采用雌激素、钙剂和氟化物防治骨折、骨质软化和骨质硬化。据报道,长期使用氟化钠治疗可增加骨折的发生率且骨质密度降低。本文作者也发现饮用高氟水的妇女骨折率显著高于饮低氟水者。为进一步阐明两者间的关系,作者采用前瞻性调查分析了高氟、高钙和对照组3种不同氟接触水平的妇女骨折率和骨质改变情况。
The health and economic costs of fractures, osteoporosis and reduced bone mineral density are quite high. Estrogen, calcium and fluoride are currently used to prevent fractures, osteomalacia and osteopetrosis. It has been reported that prolonged use of sodium fluoride increases the incidence of fractures and decreases bone density. The authors also found that women who consumed high-fluoride water had a significantly higher fracture rate than those who consumed low-fluoride water. To further elucidate the relationship between the two, the authors used prospective surveys to analyze the changes in rates of fractures and changes in women with three fluoride exposure levels in high-fluoride, high-calcium and control groups.