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腹侧基底丘脑(ventrobasal thalamus,VB)包括腹外侧核和腹后中间核,是伤害性信息传递到大脑皮层的重要中继站。已有研究表明,VB核团接受丘脑网状核(thalamic reticular nucleus,TRN)GABA能投射。TRN的GABA能抑制神经元主要通过作用于VB核团中的GABAA受体起调控作用。到目前为止,VB核团GABA能传递是否参与慢性炎症痛的发病机制,尚不清楚。本研究以完全弗氏佐剂(complete Freund’s
Ventrobasal thalamus (VB), including the ventral lateral nucleus and the ventral midbrain, is an important relay for the transmission of nociceptive information to the cerebral cortex. It has been reported that VB nuclei receive GABA projection from thalamic reticular nucleus (TRN). GABA in TRN inhibits neuronal activation primarily through GABAA receptors acting in the VB nucleus. So far, it is unclear whether VB nucleus GABA can be involved in the pathogenesis of chronic inflammatory pain. In this study, complete Freund’s adjuvant