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S-100~+树突状细胞(S-100~+DC)被认为参与抗肿瘤免疫反应,在恶性肿瘤的发生、进展过程具有重要的生物学作用.对其免疫生物学功能的深入了解,可能为肿瘤的免疫治疗开辟新途径.我们对375例癌病人(喉鳞癌50例,口腔鳞癌60例,胆囊腺癌30例,乳腺癌235例)及喉乳头状瘤、慢性胆囊炎病人各20例的病变组织、切除淋巴结内的树突状细胞,进行抗 S-100~+蛋白的免疫组化定量或半定量 S-100~+DC的检查并结合临床病理比较分析.结果S-100~+DC的检出率,喉鳞癌组织为46%,明显低于喉乳头状瘤90%(P<0.05)S-100~+DC较高密度(>4/Hp)在口腔高分化鳞癌组织为53%,明显高于中分化16.7%与低分化癌10%(P<0.05);S-100~+
S-100~+ dendritic cells (S-100~+DC) are thought to be involved in anti-tumor immune responses and have important biological effects in the development and progression of malignant tumors. The in-depth understanding of their immunobiological functions, It may open up new ways for tumor immunotherapy. We have 375 cases of cancer patients (laryngeal squamous cell carcinoma 50 cases, oral squamous cell carcinoma 60 cases, gallbladder adenocarcinoma 30 cases, breast cancer 235 cases) and laryngeal papilloma, chronic cholecystitis Twenty lesions and dendritic cells in the lymph nodes were removed. Immunohistochemical quantification of anti-S-100~+ protein or semi-quantitative examination of S-100~+DC was performed and combined with clinical pathological analysis. Results S- The detection rate of 100~+DC was 46% in laryngeal squamous cell carcinoma, which was significantly lower than that in laryngeal papilloma 90% (P<0.05). Higher density in S-100~+DC (>4/Hp) in oral cavity Squamous cell carcinoma was 53%, significantly higher than moderately differentiated 16.7% and poorly differentiated carcinoma 10% (P<0.05); S-100~+