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藻酸双酯钠(PSS)是一种新的类肝素药物.具有降血脂及降血粘度的作用.近几年来PSS广泛应用于缺血性脑、心血管疾病,其胃肠道不良反应轻微.但引起白细胞减少者临床报道不多.我院1993年6—12月住院病人中,应用PSS者252人.21例出现白细胞减少、现报告如下.1 临床资料1.1 一般资料 服用PSS 252人均为住院病人,其中高血压病41人、冠心病(包括心绞痛、急性心肌梗塞恢复期)92人、脑梗塞78人、脑出血恢复期10人、脑动脉硬化引人.发生白细胞减少者21例,发病率为8.33%,其中冠心病15例、脑梗塞6例;男16例,女5例;年龄50—70岁.1.2 用药方法及用量 上海利生制药厂生产的PSS片剂,规格50mg,100mg/次,一日三次口服.配合其他扩血管药物应用.
Sodium alginate (PSS) is a new heparinoid drug with the function of lowering blood fat and lowering blood viscosity. In recent years, PSS has been widely used in ischemic brain and cardiovascular diseases with mild gastrointestinal adverse reactions .But the clinical reports of leukopenia is not much .In our hospital from June to December 1993 inpatients, the application of PSS in 252.21 cases of leukopenia are reported as follows.1 Clinical data 1.1 General information on average PSS 252 Inpatients, including hypertension in 41, coronary heart disease (including angina, acute myocardial infarction convalescent) 92 people, 78 cerebral infarction, cerebral hemorrhage recovery period of 10 people, cerebral arteriosclerosis introduced in. Occurrence of leukopenia in 21 cases, Incidence rate of 8.33%, of which 15 cases of coronary heart disease, cerebral infarction in 6 cases; 16 males and 5 females; aged 50-70 years old .1.2 medication and dosage of PSL tablets produced by the Shanghai Lisheng Pharmaceutical Factory specifications 50mg, 100mg / Times, three times a day orally. With other vasodilator drug applications.