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目的研究CA125、CA15-3在乳腺癌中的表达及其在诊断、治疗中的临床意义。方法应用化学发光法检测40例Ⅰ-Ⅱ期乳腺癌患者、40例Ⅲ-Ⅳ期乳腺癌患者、40例良性乳腺病患者及40例正常成人血清中的CA125、CA15-3水平。结果40例Ⅲ-Ⅳ期乳腺癌患者CA125、CA15-3水平明显高于正常体检者、良性病变者和Ⅰ-Ⅱ期乳腺癌患者(P<005)。结论CA125、CA15-3在乳腺癌Ⅲ-Ⅳ期患者中有明显升高,对乳腺癌有一定的诊断价值。
Objective To study the expression of CA125 and CA15-3 in breast cancer and its clinical significance in diagnosis and treatment. Methods The levels of CA125 and CA15-3 in 40 cases of stage Ⅰ-Ⅱ breast cancer, 40 cases of stage Ⅲ-Ⅳ breast cancer, 40 cases of benign breast disease and 40 cases of normal adult serum were detected by chemiluminescence method. Results The levels of CA125 and CA15-3 in 40 patients with stage Ⅲ-Ⅳ breast cancer were significantly higher than those in normal subjects, benign lesions and stage Ⅰ-Ⅱ breast cancer (P <0.05). Conclusion CA125 and CA15-3 are significantly elevated in patients with stage Ⅲ-Ⅳ breast cancer and have certain diagnostic value in breast cancer.