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目的 探讨胰岛素样生长因子I(IGF -I)与胎儿宫内发育迟缓 (IUGR)的关系。方法 用放射免疫分析法 ,测定 36例IUGR(实验组 )和 4 2例正常晚期妊娠妇女 (对照组 )血清、羊水和脐静脉血清IGF -I的浓度。结果 IUGR组孕妇血清IGF -I浓度较对照组明显降低 ,2者相比差异有显著意义 (P <0 0 1)。IUGR组脐静脉血清IGF -I浓度明显低于对照组 ,2者相比差异有显著意义 (P <0 0 1)。结论 IGF -I可能与IUGR的发生有关。
Objective To investigate the relationship between insulin-like growth factor I (IGF-I) and intrauterine growth retardation (IUGR). Methods Serum levels of amniotic fluid and umbilical vein were measured by radioimmunoassay in 36 cases of IUGR (experimental group) and 42 normal pregnant women (control group). Results The level of serum IGF-I in pregnant women with IUGR group was significantly lower than that in control group (P <0.01). The concentration of IGF-I in umbilical vein of IUGR group was significantly lower than that of control group, the difference was significant (P <0.01). Conclusion IGF-I may be related to the occurrence of IUGR.