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60Coγ射线和苯并芘作用后,人胚肺细胞HPRT基因突变频率明显增加,表明60Coγ射线和苯并芘均造成了人胚肺细胞HPRT基因突变位点的突变损伤。HPRT基因突变与60Coγ射线和苯并芘作用剂量之间存在着良好的线性正相关的剂量效应关系,线性相关系数分别为0.9984和0.9793,显著性检验P值均小于0.01。γ射线合并苯并芘复合作用后,人胚肺细胞HPRT变异系数明显地高于对照组的同时,与单纯γ射线或苯并芘作用组比较,亦显著性地增高。复合作用组细胞HPRT变异系数高于单纯γ射线及苯并芘作用组细胞HPRT变异系数之和,表明60Coγ射线合并苯并芘诱发人胚肺细胞HPRT基因突变具有复合加强作用
The frequency of HPRT gene mutation in human embryo lung cells increased obviously after 60Coγ-ray and benzopyrene, which indicated that both 60Coγ-ray and benzopyrene caused the mutation damage of HPRT gene in human embryo lung cells. There was a good linear and positive dose-response relationship between HPRT gene mutation and 60Coγ-ray and benzopyrene dose. The linear correlation coefficients were 0.9984 and 0.9793, respectively. The P values of significance test were all less than 0.01. After γ-ray combined with benzopyrene, the coefficient of variation of HPRT of human embryo lung cells was significantly higher than that of the control group, and also significantly increased compared with the group of pure γ-ray or benzopyrene. The coefficient of variation (HPRT) of HPRT cells in the combination group was higher than that of the HPRT group in the group of pure γ-ray and benzopyrene, indicating that the combination of 60Coγ-ray and benzopyrene could induce the HPRT mutation in human embryonic lung cells