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用丝线缝扎豚鼠后牙牙颈部，并给喂养高糖食料，结果发现：实验１周时牙龈指数和牙周袋深度增加；２周时牙龈固有层有较多的淋巴细胞和浆细胞浸润，牙槽嵴处有少数破骨细胞；４周时固有层有许多浆细胞和巨噬细胞，牙槽嵴轻度吸收，有大量破骨细胞位于骨吸收陷窝处；８周时牙槽骨吸收较明显，牙槽嵴处除有大量破骨细胞外．还有成骨细胞位于骨吸收陷窝处。淋巴细胞内溶酶体和粗面内质网增多，破骨细胞多核，突起明显，内含大量溶酶体、线粒体和粗面内质网，破骨能力较强，表明丝线缝扎和高糖食料喂养豚鼠４周时形成牙周炎。
The results showed that the gingival index and periodontal pocket depth increased 1 week after the experiment; there were more infiltration of lymphocytes and plasma cells in the gingival lamina propria at 2 weeks, There were a few osteoclasts in the alveolar crest. There were many plasma cells and macrophages in the lamina propria at 4 weeks. The alveolar crest was mildly absorbed and a large number of osteoclasts were located in the bone resorption lacuna. At 8 weeks, the alveolar bone was absorbed more obviously In addition to alveolar ridge with a large number of osteoclasts. Osteoblasts are also located in the bone resorption lacuna. Lymphocyte endoplasmic reticulum and rough endoplasmic reticulum, osteoclast multi-core, prominent process, containing a large number of lysosomes, mitochondria and rough endoplasmic reticulum, osteoclasts, indicating that the suture and high sugar Food-fed guinea pigs formed periodontitis at 4 weeks.