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目的:探讨持续性肾脏替代治疗(CRRT)对多脏器功能障碍综合征(MODS)患者炎症因子和内皮细胞激活的影响。方法:将2010年1月至2012年10月收治的80例MODS患者随机分为对照组和实验组各40例,分别应用常规治疗和CRRT治疗。对照组在诊断MODS后及治疗24 h后采集静脉血,实验组在诊断MODS后进行CRRT治疗前1h及治疗24 h后采集静脉血,比较两组不同时点血浆炎性介质白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、血管生成素-2(Ang-2)及肿瘤坏死因子-α(TNF-α)的浓度。结果:实验组血浆各炎性介质较对照组均明显下降,P<0.05。结论:CRRT治疗MODS患者可有效地清除血浆中炎性介质水平,改善血管内皮功能。
Objective: To investigate the effect of continuous renal replacement therapy (CRRT) on inflammatory cytokines and endothelial cell activation in patients with multiple organ dysfunction syndrome (MODS). Methods: From January 2010 to October 2012, 80 patients with MODS were randomly divided into control group and experimental group, 40 cases were treated with conventional therapy and CRRT respectively. Venous blood was collected in the control group and 24 h after the diagnosis of MODS. Venous blood was collected in the experimental group 1 h before and 24 h after the diagnosis of MODS. Plasma levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), angiopoietin-2 (Ang-2) and tumor necrosis factor-α (TNF- Results: Compared with the control group, the inflammatory mediators in the experimental group were significantly decreased (P <0.05). Conclusion: Patients with MODS treated with CRRT can effectively clear the inflammatory mediators in plasma and improve endothelial function.