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目的分析250株鲍曼不动杆菌流行病学特点及抗菌药物耐药情况。方法使用全自动微生物鉴定仪鉴定分离的菌株,并采用纸片扩散法(K-B法)对其进行药敏实验,运用whonet 5.4软件对结果进行统计处理。结果250株鲍曼不动杆菌主要来源于神经外科、重症监护室和肝胆外科的痰液标本;药敏试验结果显示,对头孢类具有较高耐药率,对碳青霉烯类抗菌药物亚胺培南和美罗培南的耐药率分别为19.8%和29.7%;对头孢哌酮/舒巴坦敏感性较高,约92.8%。结论鲍曼不动杆菌临床耐药形势严峻,对碳青霉烯类抗菌药物也具有较高的耐药率,临床医师应严格按照实验室出具的药敏报告给药。
Objective To analyze the epidemiological characteristics of 250 strains of Acinetobacter baumannii and the antibiotic resistance. Methods The isolated strains were identified by automatic microbial identification instrument and susceptible test was carried out by disk diffusion method (K-B method). The data were analyzed by whonet 5.4 software. Results 250 strains of Acinetobacter baumannii mainly originated from sputum samples of neurosurgery, intensive care unit and hepatobiliary surgery. The results of drug susceptibility test showed that there were high rates of resistance to cephalosporins, The rates of resistance to amipenem and meropenem were 19.8% and 29.7%, respectively. The sensitivity to cefoperazone / sulbactam was 92.8%. Conclusion Acinetobacter baumannii clinical situation is grim, carbapenem antibacterial drugs also have a higher resistance rate, clinicians should be strictly in accordance with the laboratory drug sensitivity report.