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应用日本新构建的对硝基多环芳烃具有高敏感性的鼠伤寒沙门氏菌株 YG1021 和 YG1024,对北京市民用蜂窝煤和液化石油气燃烧颗粒物的丙酮提取物进行了致突变研究。结果显示,两种提取物均具有明显的间接和直接致突变作用。表明颗粒物中不仅含有多环芳烃类的间接致突变物,而且还含有直接致突变的硝基多环芳烃。从单位重量提取物的所致回变菌落数及出现阳性结果的最低剂量可见,液化石油气燃烧颗粒物的致突变活性明显高于燃煤颗粒物;YG 菌株更适用于环境样品中硝基多环芳烃的致突变活性检测。
In this study, we used the newly constructed Japanese Salmonella typhimurium strains YG1021 and YG1024 with high sensitivity to nitro-PAHs to study the mutagenicity of acetone extract from civil honeycomb coal and LPG combustion particles in Beijing. The results show that both extracts have obvious indirect and direct mutagenic effects. This indicates that the particles contain not only indirect mutagens of polycyclic aromatic hydrocarbons but also direct mutagenized nitro polycyclic aromatic hydrocarbons. The results showed that the mutagenic activity of liquefied petroleum gas (LPG) combustion particles was significantly higher than that of coal-fired particulates from the number of returned colonies and the lowest dose of positive results. The YG strain was more suitable for the determination of nitro-polycyclic aromatic hydrocarbons Mutagenic activity test.