丙型肝炎病毒感染除造成持续肝脏损伤,导致肝硬化和肝癌外,还常常引起许多肝外自身免疫现象,诸如自身抗体产生、混合性冷球蛋白血症、自身免疫性甲状腺疾病等。慢性丙型肝炎合并自身免疫性疾病的临床表现复杂,病情轻重不一,诊断难度较大。由于目前尚无统一治疗指南,治疗方案应涵盖针对病因、发病机制和对症治疗三个部分,并强调个体化治疗的重要性。 In addition to causing persistent liver damage, leading to cirrhosis and liver cancer, hepatitis C virus infection often causes many extrahepatic autoimmune phenomena such as autoantibodies, mixed cryoglobulinemia, autoimmune thyroid disease and the like. The clinical manifestations of chronic hepatitis C complicated with autoimmune diseases are complex, the severity varies, and the diagnosis is difficult. Because there is no unified treatment guide, the treatment plan should cover the etiology, pathogenesis and symptomatic treatment of three parts, and emphasize the importance of individualized treatment.