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应用免疫组化ＡＢＣ及ＬＳＡＢ法，对２７例胰岛肿瘤和３例胰岛增生进行Ｉｎｓ，Ｇａｓ，Ｇｌｕ，Ｓｏｍ，Ｓｅｒ，ＶＩＰ，ＰＰ，ＮＳＥ，ＣＨＧ，ＳＹＰ，ｈＣＧ，ＥＭＡ，Ｋ及ＣＫ的研究。结果显示：胰岛素瘤及胰岛增生Ｉｎｓ均阳性，Ｉｎｓ阳性程度与临床症状的轻重无关。胰岛素肿瘤多数为混合性的，而增生基本上是单一的，免疫反应强度与细胞分化程度有关，而与组织学类型无关；无功能性肿瘤仅表现个别激素的弱阳性。ＮＳＥ，ＣＨＧ及ＳＹＰ均是胰岛肿瘤的良好标记，它们与ＥＭＡ及Ｋ（ＣＫ）联合使用，有助于胰岛内分泌肿瘤与外分泌肿瘤的鉴别；ｈＣＧ有助于鉴别胰岛素肿瘤的良恶性。
The immunohistochemical ABC and LSAB methods were used to study Ins, Gas, Glu, Som, Ser, VIP, PP, NSE, CHG, SYP, hCG, EMA, K and CK in 27 cases of islet tumor and 3 cases of islet hyperplasia. The results showed that: Insulinoma and Ins were all positive for Ins, and the degree of Ins was not related to the severity of clinical symptoms. Insulin tumours are mostly mixed, and the proliferation is basically single, the intensity of the immune response is related to the degree of cell differentiation, but not to the type of histology; the non-functional tumours are only weakly positive for individual hormones. NSE, CHG and SYP are all good markers of islet tumors. They are used in combination with EMA and K (CK) to help differentiate between endocrine and exocrine tumors of the pancreas. hCG can help differentiate between benign and malignant insulinomas.