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目的探讨血管内皮生长因子(VEGF)在脑白质疏松(LA)患者中的临床意义。方法用酶联免疫分析法测定45例LA患者和20例健康人血清VEGF的含量。将LA患者根据其严重程度分为4级,同时又根据是否合并脑梗死分为伴脑梗死组与不伴梗死组,然后比较不同级别和不同组别患者的血清VEGF的含量。结果除LAI组患者血清VEGF的含量与正常对照组比较无统计学意义外,其余3组的VEGF含量均显著高于正常对照组(P<0.01),而且随脑白质疏松严重程度的加重而血清VEGF的含量也随之明显升高(P<0.05或P<0.01)。伴脑梗死组LA患者血清VEGF含量明显高于不伴脑梗死组(P<0.01)。结论VEGF与LA的发生发展有着一定的关系,血清VEGF含量可以反映LA的严重程度以及脑缺血的严重性。
Objective To investigate the clinical significance of vascular endothelial growth factor (VEGF) in patients with leukoaraiosis (LA). Methods Serum levels of VEGF in 45 patients with LA and 20 healthy controls were determined by enzyme-linked immunosorbent assay. Patients with LA were divided into 4 grades according to their severity. At the same time, they were divided into cerebral infarction group and non-infarcted group according to whether they were complicated by cerebral infarction or not. Then the serum levels of VEGF in different grades and groups were compared. Results The levels of VEGF in LAI group were significantly higher than those in normal control group (P <0.01), and the levels of VEGF in LAI group were significantly higher than those in normal control group VEGF content also significantly increased (P <0.05 or P <0.01). Serum VEGF levels in patients with cerebral infarction were significantly higher than those without cerebral infarction (P <0.01). Conclusions There is a relationship between VEGF and the occurrence and development of LA. The serum level of VEGF can reflect the severity of LA and the severity of cerebral ischemia.