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目的：探讨低剂量电离辐射对荷瘤机体免疫功能的影响。方法：采用 Ｃ５７ Ｂ Ｌ／６ Ｊ小鼠右后肢腓肠肌内接种 ｌｅｗ ｉｓ 肺癌细胞做为实验动物模型，在肿瘤接种后 １０ ｄ，给予 ７５ ｍ Ｇｙ Ｘ 射线全身照射，于照射后 １８ ｈ 测定荷瘤小鼠胸腺、脾脏某些免疫学参数的变化，包括胸腺细胞自发增殖力、脾细胞数，脾细胞对 Ｃｏｎ Ａ、 Ｌ Ｐ Ｓ反应性，脾细胞白细胞介素（ Ｉ Ｌ２）分泌量，脾脏自然杀伤细胞（ Ｎ Ｋ）、淋巴因子激活的杀伤细胞（ Ｌ Ａ Ｋ）、特异性细胞毒性 Ｔ 淋巴细胞（ Ｃ Ｔ Ｌ）杀伤活性。结果：与荷瘤假照射组相比，７５ ｍ Ｇｙ Ｘ 射线照射组小鼠的上述免疫学参数明显提高（ Ｐ＜ ００５～０１）。结论：低剂量电离辐射可明显增强荷瘤机体的免疫功能，可能具有肿瘤治疗的潜在临床意义。
Objective: To investigate the effects of low-dose ionizing radiation on the immune function of tumor-bearing mice. METHODS: Lew is lung cancer cells were inoculated intramuscularly into the right hind limbs of C57B L/6 J mice as an experimental animal model. After 10 days of tumor inoculation, whole body irradiation with 75 m Gy X-rays was performed. The tumor was measured 18 h after irradiation. Changes in some immunological parameters of thymus and spleen in mice, including thymocyte spontaneous proliferation, number of splenocytes, reactivity of splenocytes to Con A and L P S, secretion of interleukin (IL-2) in spleen cells, Splenic natural killer (NK), lymphokine-activated killer (LAK), and cytotoxic T lymphocyte (CTL) killing activity. RESULTS: Compared with the tumor-implanted sham group, the above-mentioned immunological parameters of the 75 m Gy X-irradiated group were significantly increased (P < 005～01). CONCLUSION: Low-dose ionizing radiation can significantly enhance the immune function of the tumor-bearing organism and may have potential clinical implications for tumor treatment.