论文部分内容阅读
目的探讨荷芩止痒搽剂对艾滋病皮肤瘙痒症的作用及作用机制。方法将研究病例分为自然病程组和荷芩止痒搽剂组,每组各20例,获得完整数据资料的患者38例,其中自然病程组30例,荷芩止痒搽剂组38例,疗程均为1月,分别于治疗前(0)月、1月对两组病例患者进行随访,对荷芩止痒搽剂的临床疗效进行观察、判定,对患者的生活质量进行评分,并抽取静脉血检测患者外周血嗜酸粒细胞计数、血浆IL-5含量变化情况。结果在治疗满1月时,荷芩止痒搽剂组患者临床症状评分明显降低,与治疗前、自然病程组相比差异均有统计学意义(P<0.05),临床疗效显著(P<0.05),DQOLS积分虽然与自然病程组相比无明显提高,但较治疗前有明显提高;在实验室指标方面,荷芩止痒搽剂可明显降低艾滋病皮肤瘙痒症患者的嗜酸性粒细胞计数,但不能降低患者血浆IL-5的含量(P>0.05)。结论荷芩止痒搽剂能较好地改善艾滋病皮肤瘙痒症患者临床症状且疗效明显,可明显降低患者的嗜酸性粒细胞计数,但不能降低患者血浆IL-5的含量。
Objective To investigate the effect and mechanism of QQLI on pruritus AIDS. Methods The study cases were divided into natural course group and QQI group, 20 cases in each group, and 38 cases were obtained complete data, of which 30 cases were from natural course group, 38 cases were treated with QKL, The course of treatment was January. The patients in both groups were followed up before (0) month and January respectively. The curative effect of QQTB was observed and judged. The quality of life of the patients was scored and taken Venous blood test patients with peripheral blood eosinophil count, plasma IL-5 levels. Results The scores of clinical symptoms in QQLI group were significantly decreased at 1 month of treatment, with statistical significance (P <0.05) compared with those before treatment and in natural course group (P <0.05) ), Although the DQOLS score compared with the natural course of disease did not significantly improved, but significantly improved compared with before treatment; in laboratory indicators, the lotus root antipruritic liniment can significantly reduce AIDS skin pruritus patients eosinophil count, But can not reduce the plasma IL-5 content (P> 0.05). Conclusion QQRI can improve the clinical symptoms of AIDS and pruritus in patients with obvious curative effect, can significantly reduce the patient’s eosinophil count, but can not reduce the content of plasma IL-5.