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核因子-κB(NF-κB)在机体炎症、免疫、凋亡及细胞生长分化等过程中发挥关键作用。妊娠期研究显示,NF-κB激活决定着受精卵植入时间,妊娠成功与否与NF-κB对凋亡过程控制密切相关;早产和分娩发动均有NF-κB激活,其阻滞剂可预防早产,是早产治疗和药物研究的新方向;正常妊娠外周血单核细胞(PBMC)中NF-κB被抑制而保护胎儿,子痫前期胎盘NF-κB激活与其发生及病理有关,妊娠期糖尿病(GDM)胎盘对激活NF-κB应激反应迟钝。揭示NF-κB与妊娠的关系有待深入大量的研究。
Nuclear factor-κB (NF-κB) plays a key role in inflammation, immunity, apoptosis and cell growth and differentiation. Pregnancy studies have shown that NF-κB activation determines fertilization egg implantation time, pregnancy success or not and NF-κB is closely related to the process of apoptosis control; premature labor and labor onset NF-κB activation, and its blockers preventable Premature delivery is the new direction of premature delivery and drug research. NF-κB in normal pregnancy peripheral blood mononuclear cells (PBMCs) is inhibited to protect the fetus. Activation of NF-κB in preeclampsia placenta is related to its occurrence and pathology. Gestational diabetes mellitus GDM) The placenta is unresponsive to activating NF-κB stress. Reveal the relationship between NF-κB and pregnancy needs further research.