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Objective To research treatment effect of microwave heat coagulation assisted laser and local chemotherapy under fibrobronchoscope for the acute respiratory distress from intratracheal tumor or metastasis neoplasia, and assess quality of life after treatment. Method In the emergency, applied microwave histological coagulation treatment under fibrobronchoscope to 2 patients of acute respiratory distress, even asphyxia from intratracheal tumor or metastasis tumor. Removed the mass, and assisted laser and local chemotherapy necessarily to relieve respiratory distress. Observed quality of life. Results The intratracheal mass of 2 patients were eliminated completely, distress and asphyxia were relieved and there were no severe side effects. The patients lived over 6 months, completed self care, and joined the light physical strength labor. The muscle power also reach Ⅳ level fromⅠ level. Conclusion The treatment of microwave histological coagulation assisted laser and local chemotherapy is one good method to relieve the respiratory distress or asphyxia from late intratracheal tumor or transmission tumor, and promote quality of life obviously.